14:00 Registration: Faculté de Médecine de Monastir
17:00 Opening Ceremony: Faculté de Médecine de Monastir
17 :40 Introductory lecture
Helmut Sies
Institute for Biochemistry and Molecular Biology I, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
"How do they work? Biological aspects and mechanisms: Beyond the antioxidant mechanism”
18:30 Welcome Reception
Sunday, October, 12th 2008 Morning
8:00 Registration-El Mouradi Palace (El Kantaoui – Sousse)
Plenary Session 1 Conference Room 1
Advances in trace element analysis and functions
9:00 Bernhard Michalke
Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Ecological Chemistry, Neuherberg, Germany.
“Element speciation definitions, analytical methodology and useful fields”
9 :30 Alain Favier & Walid Rachidi
Département de Biologie Intégrée, Pôle de biologie, CHU de Grenoble, Grenoble, France.
"Interactions between Trace elements and Human Genome"
10:00-10:30 Coffee Break
Plenary Session 2 Conference Room 1
Zinc from molecular aspects to benefits for human health
10:30 Ananda S. Prasad
Department of Internal Medicine, Wayne State University School of Medicine, Detroit Michigan, USA
"New advances in zinc and immunity"
11:00 Calogero Caruso
Department of Pathobiology and Biomedical Methodology, University of Palermo, Palermo, Italy
"Zinc and inflammatory/Immune response in aging"
11:30 Christopher Frederickson
NeuroBioTex Inc., Department of Preventive Medicine and Community Health, the University of Texas Medical School, Galveston, USA
«Zinc signaling in the brain and other organs»
12 :00 Michel Sève
Laboratoire des lésions des acides nucléiques, DRFMC/SCIB/LAN, CEA/Grenoble, France.
“Mammalian Zinc transporters with a special focus on Zinc transporter 8 (SLC30A8) and diabetes: a promising new diagnostic and therapeutic target”
12:30 Lunch
13:30-14:30 Poster's Session I and II
Sunday, October, 12th 2008 Afternoon
Two Concurrent Sessions ( 3 and 4 )
Plenary Session 3 Conference Room 1
Wilson disease (1)
14:30 Amri Fathi 1 and Tahar Sfar 2
1: Hôpital Universitaire Kairouan, Tunisia.
2: Hôpital Universitaire Mahdia, Tunisia.
« La maladie de Wilson chez l’enfant en Tunisie »
15:00 Bost Muriel1,2,3, Piguet-Lacroix Gwanaelle1,3, Pelosse Martine3, Guillaud Olivier3, Broussolle Emmanuel3,4, Xie-Brustolin Jing3,4, Dumortier Jérôme3,5, Lachaux Alain3,6
1) Neurogénétique moléculaire et Réseau des Maladies héréditaires du métabolisme, Centre de Biologie, Groupe Hospitalier Est, Lyon – 2) Trace Element-Institute for Unesco, Lyon – 3) Centre de Référence Maladie de Wilson, Département de Pédiatrie, HFME, Lyon – 4) Service de Neurologie, Hôpital Neurologique, Lyon – 5) Fédération des spécialités digestives, Hôpital Edouard Herriot, Lyon – 6) Unité d’Hépatogastroentérologie infantile, Département de Pédiatrie, Hôpital Femme Mère Enfant, Lyon - France
“Mutation analysis in Wilson disease: direct sequencing and identification of gene deletions by Multiplex Ligation-dependent Probe Amplification (MLPA) in ATP7B gene”
15:30 Lachaux Alain1,2, Guillaud Olivier 1,3, Dumortier Jérome1,3, Rivet Christine 1,2, Brunet Anne Sophie1,2, Bost Muriel14,
1) Centre de référence pour la maladie de Wilson - 2) Service de Gastroentérologie, Hépatologie et Nutrition Pédiatriques, Hôpital Femme Mère Enfant, Bron. 3) Unité de transplantation hépatique, Hôpital Edouard Herriot, Lyon - 4) Laboratoire de Neurogénétique et des Maladies héréditaires du métabolisme, GHE, Bron
“Les formes hepatiques de la maladie de Wilson"
Plenary Session I Conference Room 2
- 14:30-16:00 Oral Communication's Session I
16: 00-16:30 Coffee Break
Plenary Session 5 Conference Room 1
Wilson disease (2)
16:30 Trocello Jean-Marc, Chappuis Philippe, Chaine Pascal, Woimant France
Centre Maladie Rare Bernard Pépin pour la Maladie de Wilson
Service de neurologie, hôpital Lariboisière, Paris, France
"Maladie de Wilson:formes neurologiques de l'enfant à l'adulte et traitements"
17:00 Woimant France, Trocello Jean-Marc, Lachaux Alain, Bost Muriel
Centre Maladie Rare Bernard Pépin pour la Maladie de Wilson
Service de neurologie, hôpital Lariboisière, - Paris, France
"Centre National de Référence de la Maladie de Wilson"
17:30 Poster's Wilson disease
Plenary Session II Conference Room 2
16:30-18:45 Oral Communication's session II
Monday, October 13th, 2008 Morning
8 :00 Registration - El Mouradi Palace
Plenary Session 1 Conference Room 1
Trace elements and Neurodegenerative diseases
8:30 Julie K. Andersen
Buck Institute for Age Research Novato, USA
“Iron and Parkinson’s disease”
9:00 Paolo Zatta and Silvia Bolognin
CNR- Institute for Biomedical Technologies, “Metalloproteins” Unit, Department of Biology, University of Padova, Padova, Italy
"Copper deficiency and neurological disorders in man and animals"
9:30 Vincent Gallicchi 1 and Guy Chazot 2
1: Office of Sponsored Programs, Clemson University, Clemson, USA
2: Trace Element-Institute for UNESCO, Lyon, France
«Lithium and the prevention of Alzheimer’s disease"
10:00-10:30 Coffee Break
Plenary Session 2 Conference Room 1
Oxidative stress and cellular dysfunction
10:30 Jose Vina
Departmento de Fisiologia, facultad de medicina, Valencia, Spain.
“Regulation of the expression of longevity-associated genes”
11 :00 Jacques Huot
Centre de recherche en cancérologie de l'Université Laval L'Hôtel-Dieu de Québec Canada
"Tropomyosin-1, a key regulator of the oxidative stress response in endothelial cells."
11:30-12:30- Oral Communication's session III Conference Room 1
11:30-12:30- Oral Communication's sessions IV Conference Room 2
12:30 Lunch
13:30-15:00 Poster's Session III & IV
Monday, October 13th, 2008 Afternoon
Plenary Session 3 Conference Room 1
Micronutrients and other biofactors modulating hormones
15:00 R. Anderson
Beltsville Human Nutrition Research Center, Washington DC, USA
“Polyphenols, insulinoresistance and brain”
15:30 Joseph Koehler
Institute for Experimental Endocrinology, Charité, University Medical School, Berlin Germany
“The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health”
16:00-16:30 Coffee Break
Plenary Session 4 Conference Room 1
Aging and Nutrition
16 :30 Anne-Marie Roussel
INSERM 884, Université de Grenoble, Grenoble, France.
"Antioxidant micronutrients : benefits and limits in aging prevention » Report from the IANA task force
17:00 Eugenio Mocchegiani
Immunology Centre,Italian National Research Centre on Ageing ( INRCA), Ancona, Italy
Results of “European ZINCAGE” Project
17:30-18:30- Oral Communication's session V Conference Room 1
17:30-18:30- Oral Communication's session VI Conference Room 2
Tuesday, October 14th, 2008 Morning
8:00 Registration –El Mouradi Palace
Plenary Session 1 Conference Room 1
Oxidant stress and Neurodegenerative diseases
9:00 A.Kerkeni and M.Frih-Ayed
Faculté de Medecine de Monastir Tunisia
“Oxidative stress and neurodegenerative disorders”
9:30 Kim Q.Do
Center for Research in Psychiatric Neuroscience, University of Lausanne, Switzerland
“Metabolism and functions of glutathione in brain: Relevance to schizophrenia”
10:00-10:30-Coffee Break
Plenary Session 2 Conference Room 1
Prostate cancer and micronutrients
10:30 Saverio Bettuzzi
Departemanto di Medicina Sperimentale, Sezione di Biochimica, Universita di Parma, Italy.
“Polyphenols and prostate cancer”
11:30 Jean Nève
Université libre de Bruxelles, Institut de Pharmacie, Bruxelles, Belgium.
“Selenium and prostate cancer”
12:00 Renty B. Franklin
Department of Biomedical Sciences Dental School, University of Maryland, Baltimore, USA
“Zinc as an anti-tumour agent in prostate cancer and in other cancers”
12:30 - Lunch
13:30-15:00 Poster's session V and VI
Tuesday, October 14th, 2008 Afternoon
Two Concurrent Sessions ( 3 and 4)
Plenary Session 3 Conference Room 1
Ocular diseases
15:00 Moncef Khairallah
Hôpital Universitaire Fattouma Bourguiba Monastir, Tunisia
« Ocular diseases ”
15:30 Alberto Izzotti
Department of Health Sciences, University of Genoa, Genoa, Italy.
“The role of oxidative stress in glaucoma”
16:00-16:30 Coffee Break
Plenary Session 4 Conference Room 2
Trace elements and Environment
15:00 Momoko Chiba
International University of Health and Welfare Japan
“Seasonal variation of micronutrients ingested by local residents in semi-desert area”
15:30 Sangeeta Shukla 1 and, M Abdulla 2
1 Jiwaji University, Gwalior, India
2 Kyrkhult, Sweden
«Strategies for safe and effective therapeutic measures against occupational hazards: role of antioxidants “
16:00-16:30 Coffee Break
Plenary Session 5 Conference Room 1
Antioxidant vitamins and new antioxidants
16:30 Hamid M. Said
University of California School of Medicine, Irvine, USA
“Transport of water-soluble vitamins: Physiological, nutritional and clinical aspects”
17:00 A.V.Rao
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada.
“Carotenoids and human health”
17:30 Fathi Moussa
Faculté de Pharmacie, Université de Paris Sud, Paris, France
"Fullerenes: new antioxidant agents"
16:30-18:30- Oral Communication's session VII Conference Room 2
Wednesday, October 15th, 2008 Morning
8:00 Registration –El Mouradi Palace
Plenary Session 1 Conference Room 1
Selenium and brain development
9:00 Ulrich Schweizer
Neurobiology of Selenium, Neuroscience Search Center, Charité, University Medical school, Berlin, Germany
"Role of selenium in brain development and function"
9:30 Alain Krol
CNRS, Université Louis Pasteur de Strasbourg, Institut de Biologie Moléculaire et cellulaire, Architecture et Réactivité de l’ARN, Strasbourg, France.
"A complex molecular machinery to specifically incorporate selenocysteine into proteins important for health and disease"
10:00-10:30 - Coffee Break
Plenary Session 2 Conference Room 1
Iron and brain development
10:30 Tracey A. Rouault and Wing Hing Tong
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, USA
"Normal brain iron metabolism and the transport of iron in the post natal brain"
11:00 Michael K. Georgieff
Center for Neurobehavioral Development, Departments of Pediatrics and Child Psychology, University of Minnesota, Minneapolis, MN, USA.
"Iron deficiency and brain development"
11:30-12:30- Oral Communication's session VIII Conference Room 1
11:30-12:30- Oral Communication's session IX Conference Room 2
12:30 Lunch
Wednesday, October 15th, 2008 Afternoon
Plenary Session 3 Conference Room 1
Cardiovascular diseases and antioxidant micronutrients
14:30 Habib Gamra
Hôpital Universitaire Fattouma Bourguiba Monastir, Tunisia
"Cardiovascular diseases »
15:00 Jean-Marc Zingg
Institute of Biochemistry and Molecular Medicine, University of Bern, Buhlstrass 28, 3012 Bern, Switzerland
“Cellular, molecular and clinical aspects of Vit. E on atherosclerosis prevention”
15:30 Maria-Isabel Covas
Lipids and Cardiovascular Epidemiology Unit, Institute Municipal dilnvestigacio Medica , Parc de Recerca Biomedical de Barcelona (PRBB), Barcelona, Spain
“Olive oil and the cardiovascular system”
16:30 Sophie Ermidou-Pollet
HTES, Greece
“Antioxidant capacity of the Greek Mediterranean diet”
16:30-17:00 Coffee Break
17:00 Closure and evaluation of the Meeting